Sorry, but what is hard science? I mean, models are suppose to change over time, at least if you're doing science right. Even physics models keep changing.
I'm not sure we can say that at any point in time the FDA recommendations were bad, but simply that as more and more knowledge is acquired, old models are showed not to fit the data as well, so we come up with new models that do.
I'm not sure we can say that at any point in time the FDA recommendations were bad, but simply that as more and more knowledge is acquired, old models are showed not to fit the data as well, so we come up with new models that do.