I run Aurora and use the Add-on Compatibility Reporter[1] to disable version checks and run any add-on I want. For most of my add-ons this works fine, but if there is a significant API change an add-on might not work correctly. But if you were scared of that you wouldn't be using Nightly or Aurora.

[1]: https://addons.mozilla.org/en-US/firefox/addon/add-on-compat...