I'm using a netbook. I think without "Readability" I woudln't have been able to make it through most of their post because I kept hitting space about twice per second. From looking at their redesign for an article page (didn't care much about anything related to the wikipedia homepage, I never use it), it seems like they don't care too much for people with small screens either: about half of the available screen estate available to my browser would be covered by their menu thing at the top.
I guess people with netbooks would be worse off.